Standardized benchmarking in the quest for orthologs, Nature Methods, advanced online publication April 2016, doi:10.1038/nmeth.3830
A lot of effort is put into designing methods to find genes – known as orthologs – that are directly related in different species. Unearthing orthologs is essential for many comparative, evolutionary and functional genomic analyses, and the higher the accuracy the better the analyses. The task, however, is not an easy one. When two species diverge, their genes do not evolve in the same manner and finding ways to uncover orthologs is rarely straightforward.